Types of Blood Disorder
Blood disorders can affect any of the three main components of blood:
Blood disorders can also affect the liquid portion of blood, called plasma.
Treatments and prognosis for blood diseases vary, depending on the blood condition and its severity.
Blood disorders that affect red blood cells include:
Anemia: People with anemia have a low number of red blood cells. Mild anemia often causes no symptoms. More severe anemia can cause fatigue, pale skin, and shortness of breath with exertion.
Iron-deficiency anemia: Iron is necessary for the body to make red blood cells. Low iron intake and loss of blood due to menstruation are the most common causes of iron-deficiency anemia. Treatment includes iron pills, or rarely, blood transfusion.
Anemia of chronic disease: People with chronic kidney disease or other chronic diseases tend to develop anemia. Anemia of chronic disease does not usually require treatment. Injections of a synthetic hormone (Epogen, Procrit) to stimulate the production of blood cells or blood transfusions may be necessary in some people with this form of anemia.
Pernicious anemia (B12 deficiency): An autoimmune condition that prevents the body from absorbing enough B12 in the diet. Besides anemia, nerve damage (neuropathy) can eventually result. High doses of B12 prevent long-term problems.
Aplastic anemia: In people with aplastic anemia, the bone marrow does not produce enough blood cells, including red blood cells. A viral infection, drug side effect, or an autoimmune condition can cause aplastic anemia. Blood transfusions, and even a bone marrow transplant, may be required to treat aplastic anemia.
Autoimmune hemolytic anemia: In people with this condition, an overactive immune system destroys the body's own red blood cells, causing anemia. Medicines that suppress the immune system, such as prednisone, may be required to stop the process.
Thalassemia: This is a genetic form of anemia that mostly affects people of Mediterranean heritage. Most people have no symptoms and require no treatment. Others may need regular blood transfusions to relieve anemia symptoms.
Sickle cell anemia: A genetic condition that affects mostly African-Americans. Periodically, red blood cells change shape, and block blood flow. Severe pain and organ damage can occur.
Polycythemia vera: The body produces too many blood cells, from an unknown cause. The excess red blood cells usually create no problems but may cause blood clots in some people.
Malaria: A mosquito's bite transmits a parasite into a person's blood, where it infects red blood cells. Periodically, the red blood cells rupture, causing fever, chills, and organ damage. This blood infection is most common in Africa; those traveling to Africa are at risk and should take preventive measures. Malaria was eradicated from the U.S. in the 1940s.
Blood disorders that affect white blood cells include:
Lymphoma: A form of blood cancer that develops in the lymph system. In lymphoma, a white blood cell becomes malignant, multiplying and spreading abnormally. Hodgkin's lymphoma and non-Hodgkin's lymphoma are the two major groups of lymphoma. Treatment with chemotherapy and/or radiation can extend life with lymphoma, and sometimes cure it.
Leukemia: A form of blood cancer in which a white blood cell becomes malignant and multiplies inside bone marrow. Leukemia may be acute (rapid and severe) or chronic (slowly progressing). Chemotherapy and/or stem cell transplantation (bone marrow transplant) can treat leukemia, and sometimes result in a cure.
Multiple myeloma: A blood cancer in which a white blood cell called a plasma cell becomes malignant. The plasma cells multiply and release damaging substances that eventually cause organ damage. Multiple myeloma has no cure, but stem cell transplant and/or chemotherapy can allow people to live for years with the condition.
Myelodysplastic syndrome: A family of blood cancers that affect the bone marrow. Myelodysplastic syndrome often progresses very slowly, but may suddenly transform into a severe leukemia. Treatments usually include blood transfusions and chemotherapy. Stem cell transplant can sometimes cure younger people with myelodysplastic syndrome.
Blood disorders that affect the platelets include:
Thrombocytopenia: A low number of platelets in the blood. Numerous conditions cause thrombocytopenia; most do not result in abnormal bleeding.
Idiopathic thrombocytopenic purpura: A condition causing a persistently low number of platelets in the blood, due to an unknown cause. Usually there are no symptoms, yet abnormal bruising, small red spots on the skin (petechiae), or abnormal bleeding can result.
Heparin-induced thrombocytopenia: A low platelet count caused by a reaction against heparin, a blood thinner given to most people who are hospitalized to prevent blood clots.
Thrombotic thrombocytopenic purpura: A rare blood disorder causing small blood clots to form in blood vessels throughout the body. Platelets are used up in the process, causing a low platelet count.
Essential thrombocytosis (primary thrombocythemia): The body produces too many platelets, due to an unknown cause. The platelets do not work properly, resulting in excessive clotting, bleeding, or both.
Blood disorders that affect blood plasma include:
Sepsis: An infection somewhere in the body spreads into the blood. Symptoms include fever, rapid breathing, respiratory failure, and low blood pressure.
Hemophilia: A genetic deficiency of certain proteins that help blood to clot. There are multiple forms of hemophilia, ranging in severity from mild to life-threatening.
Von Willebrand disease: von Willebrand factor is a protein in blood that helps blood to clot. In von Willebrand disease, the body either produces too little of the protein, or produces a protein that doesn't work well. The condition is inherited, but most people with von Willebrand disease have no symptoms and don't know they have it. Some people with von Willebrand disease will have excessive bleeding after an injury or during surgery.
Hypercoaguable state (hypercoagulable state): A tendency for the blood to clot too easily. Most affected people have only a mild excess tendency to clot, and may never be diagnosed. Some people develop repeated episodes of blood clotting throughout life, requiring them to take a daily blood thinning medicine.
Deep venous thrombosis: A blood clot in a deep vein, usually in the leg. A deep venous thrombosis can dislodge and travel through the heart to the lungs, causing a pulmonary embolism.
Disseminated intravascular coagulation (DIC): A condition that causes tiny blood clots and areas of bleeding throughout the body simultaneously. Severe infections, surgery, or complications of pregnancy are conditions that can lead to DIC.
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